Lunaphore COMET is a fully automated spatial biology platform supporting high-throughput seqIF and RNAscope HiPlex. Accelerate spatial tissue analysis with flexibility and reproducibility. Includes software.
Lunaphore COMET™
The Lunaphore COMET™ is an advanced, fully automated spatial biology platform designed for high-throughput, high-plex tissue analysis. COMET™ supports both sequential immunofluorescence (seqIF™) and RNAscope™ HiPlex workflows, offering unmatched flexibility for spatial proteomics and transcriptomics research.
Powered by Lunaphore’s patented FFeX™ microfluidic technology, COMET™ delivers scalable, reproducible staining and imaging — without the need for antibody conjugation. Whether profiling immune cells in the tumour microenvironment or exploring complex tissue architecture, COMET™ allows researchers to generate robust, spatially-resolved data across dozens of markers.
With an open system design, users can choose from off-the-shelf SPYRE™ panels, their own validated antibodies, or third-party RNA probes — making assay development fast and accessible. The system supports automated panel building, image acquisition, and pre-processing, enabling users to go from slide insertion to high-quality, OME-TIFF image output with minimal intervention.
Key features:
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Spatial biology platform supporting seqIF™ and RNAscope™ HiPlex
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Fully automated workflows: staining, hybridisation, imaging, and image pre-processing
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Use standard primary antibodies — no need for conjugation or barcoding
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Compatible with FFPE and frozen tissue samples
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Perform up to 40-plex protein detection in one run
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Re-use samples for downstream analysis
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Open compatibility with image analysis tools like HALO®, Visiopharm, and QuPath
COMET™ is ideal for translational and clinical research applications in oncology, immunology, neuroscience, and infectious disease — supporting spatial biomarker discovery, validation, and pathway exploration with confidence and ease.