Biotechne MauriceFlex combines automated cIEF & CE-SDS analysis with protein charge isoform fractionation in one instrument, enabling in-depth analysis of charge variants, purity, and heterogeneity for biotherapeutics
Automated cIEF & CE-SDS analysis, and cIEF fractionation
MauriceFlex combines protein charge isoform fractionation with imaged-capillary isoelectric focusing (icIEF) and CE-SDS analysis in one instrument, so that you can go beyond routine size and charge and conduct an in-depth analysis of your molecule at any stage without needing to rely on different instruments, methods, or expertise. Get compliant data with either Compass for iCE or Waters Empower software (fractionation not supported on Empower).
Purity, identity, heterogeneity, and charge variant fractionation
The potency, safety, and efficacy of your biotherapeutic can be impacted by certain charge variants present, therefore in-depth characterization is crucial. Now, instead of spending weeks or months on ion-exchange chromatography (IEX) based fractionation, detect charge variants of your protein, AND collect their fractions on the same instrument in the same day!