Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Mouse MIP (Macrophage Inflammatory Protein)
- Overview: Mouse MIP is a small polypeptide involved in leukocyte chemotaxis and inflammation. It was first identified in macrophages in response to lipopolysaccharide (LPS) stimulation.
- Molecular Characteristics:
- Size: Approximately 8 kDa.
- Function: Acts as a chemoattractant, guiding leukocytes to sites of inflammation.
- Types Identified:
- MIP-1: Also known as MIP-1α. A CC chemokine that primarily attracts monocytes and other immune cells.
- MIP-2: Also known as MIP-2α. Similar to MIP-1 but with different target cells and specificities.
- Biological Role: Both MIP-1 and MIP-2 play crucial roles in inflammation and immune response by recruiting leukocytes to sites of infection or injury.
Mouse KC (Keratinocyte-Derived Cytokine)
- Overview: Mouse KC is a chemokine that serves as the mouse counterpart to the human GRO (Growth-Regulated Oncogene) protein.
- Production: KC is produced by activated monocytes and fibroblasts.
- Molecular Characteristics:
- Function: KC acts as a potent chemoattractant for neutrophils and other immune cells. It is involved in various inflammatory processes.
- Biological Role: KC contributes to inflammation by recruiting neutrophils and influencing other aspects of the inflammatory response. It is important for understanding conditions involving chronic inflammation and tissue repair.
Summary
Both Mouse MIP and Mouse KC are important chemokines involved in regulating immune responses. MIP, with its types MIP-1 and MIP-2, is critical for leukocyte recruitment during inflammation. KC, analogous to human GRO, plays a significant role in attracting neutrophils and modulating inflammatory processes. Their study provides insights into the mechanisms of inflammation and potential therapeutic targets for inflammatory diseases.
This ELISA Kit from Tecan IBL International is for research use only.
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