EL Full-Lenght ELISA

Endothelial Lipase (EL) Overview

Function and Role:

• Enzyme Classification: Endothelial lipase (EL) is part of the triacylglyceride lipase family.
• Synthesis and Localization: Primarily synthesized by vascular endothelial cells.
• Impact on Lipid Metabolism: EL plays a role in lipid metabolism, specifically in the hydrolysis of phospholipids and triacylglycerides.

Clinical Relevance:

• HDL-C Relationship: Research indicates an inverse relationship between EL expression and plasma High-Density Lipoprotein Cholesterol (HDL-C) levels. Higher EL levels are associated with lower HDL-C concentrations.
• Atherosclerosis and Cardiovascular Health: The inverse relationship suggests that EL may influence the development of atherosclerosis. Targeting EL could potentially help in increasing HDL-C levels and reducing cardiovascular disease risk.

Research Findings:

• Animal Models: Studies with laboratory mice lacking the EL gene or overexpressing human EL have shown similar inverse relationships between EL levels and HDL-C concentrations.
• Human Studies: Consistent findings have been observed in human subjects, reinforcing the potential of EL as a therapeutic target.

ELISA Kit Details:

• Purpose: Designed to accurately measure the concentration of endothelial lipase in serum or plasma samples.
• Sample Compatibility: Suitable for use regardless of heparin administration, ensuring reliable results across various conditions.
• Control Set: Available separately upon request.

This ELISA kit provides a valuable tool for investigating endothelial lipase's role in lipid metabolism and its potential as a target for therapeutic interventions to manage cholesterol levels and prevent cardiovascular diseases.

This ELISA Kit from Tecan IBL International is for research use only.

Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
Explore the full range >