Tecan IBL International offers a comprehensive range of ELISAs, antibodies, immunoassays and recombinant proteins for research use only.
Tecan IBL Dentin Matrix Protein 1 (DMP1)
General Characteristics:
- Family: DMP1 is a member of the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family.
- Size and Structure: Synthesized as a 105 kDa proprotein, which is then cleaved into a 37 kDa N-terminal fragment and a 57 kDa C-terminal fragment. It contains multiple acidic domains that interact with calcium.
Biological Functions:
- Bone Mineralization: DMP1 is a crucial component of the extracellular matrix in osteocytes and plays a significant role in bone mineralization. Its acidic domains facilitate calcium binding, contributing to the mineralization process.
- Osteocyte Function: Unlike other matrix proteins like Osteopontin, Osteocalcin, and Bone Sialoprotein, which are produced by osteoblasts, DMP1 is specifically expressed by osteocytes. Osteocytes are involved in regulating bone remodeling by controlling the activity of osteoclasts and osteoblasts. They also function as endocrine cells by secreting Fibroblast Growth Factor 23 (FGF-23), which regulates phosphate metabolism.
Clinical Relevance:
- Bone Health: DMP1 levels are associated with osteocyte activity and bone metabolism. Abnormal levels can indicate disruptions in bone health, such as in osteoporosis or other bone disorders.
- Biomarker Potential: DMP1 is considered a potential biomarker for assessing osteocyte activity and bone and phosphate metabolism. Its concentration in blood can be quantitatively measured using specific ELISA kits, providing insights into bone health and metabolic conditions.
Measurement and Application:
- ELISA Kit: The concentration of DMP1 in human blood can be accurately quantified using ELISA (Enzyme-Linked Immunosorbent Assay) kits. This allows for research into bone health and phosphate metabolism and can aid in monitoring and diagnosing bone-related diseases.
Summary: Dentin Matrix Protein 1 (DMP1) is a key extracellular matrix protein involved in bone mineralization and osteocyte function. As a member of the SIBLING family, it is important for bone health and metabolism. Elevated or altered levels of DMP1 in the bloodstream can serve as valuable biomarkers for studying bone disorders and phosphate metabolism, with potential applications in research and clinical diagnostics.
This ELISA Kit from Tecan IBL International is for research use only.
Tecan IBL International offers a comprehensive range of ELISAs, immunoassays, antibodies and recombinant proteins.
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