APRIL (TNF 13, CD256 antigen) ELISA

APRIL (A Proliferation-Inducing Ligand) Overview:

• Family: APRIL is a member of the Tumor Necrosis Factor (TNF) family.
• Expression: It is highly expressed in various tumors and exhibits low expression in normal cells.
• Receptors: APRIL shares receptors TACI (Transmembrane Activator and CAML Interactor) and BCMA (B-cell Maturation Antigen) with BlyS/BAFF (B-lymphocyte Stimulator/BAFF), another TNF homolog. Both TACI and BCMA are associated with autoimmune diseases and cancer.

Functions:

• T Cell Survival and Proliferation:
• APRIL plays a role in T-independent type II antigen responses.
• It supports T cell survival and proliferation.
• Non-Lymphoid Cells:
• APRIL has the capacity to induce proliferation and survival in non-lymphoid cells.
• Inflammatory Conditions:
• In patients with inflammatory arthritis, APRIL is locally produced in affected joints.
• Biologically active heterotrimers of BlyS/BAFF and APRIL are found in systemic immune-based rheumatic diseases.

Interaction with BCMA:

• Soluble BCMA Receptor:
• A soluble form of the high-affinity BCMA receptor can inhibit APRIL’s proliferative activity in vitro.
• This inhibition reduces tumor cell proliferation.
• APRIL Overexpression:
• Cells transfected with APRIL show increased tumor growth, indicating its role in promoting tumor cell proliferation.

Summary: APRIL is a TNF family member with notable implications in tumor biology and autoimmune diseases. It promotes T cell survival and proliferation, contributes to inflammatory conditions, and affects tumor cell growth. The soluble BCMA receptor's ability to inhibit APRIL’s activity presents a potential therapeutic avenue for modulating tumor growth and managing inflammatory diseases.

This ELISA Kit from Tecan IBL International is for research use only.

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